Write a 3 pages paper on hsp60 and hsp70 and their confusing roles in aging.

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Write a 3 pages paper on hsp60 and hsp70 and their confusing roles in aging.

Based on ideas gleaned from several reputable references, it remains inconclusive whether hsp70 and hsp60 indeed inhibit the aging process.

Hsp70 and hsp60 are molecular chaperones, or “abundant, well-conserved proteins responsible for the maintenance of the conformational homeostasis of cellular proteins and RNAs” and are believed to be usually induced by environmental stress (Soti & Csermely, “Molecular Chaperones” 227). In short, as molecular chaperones are often associated with aging tissues and aging in general, these proteins are especially found in such situations. There is, however, a debate whether their presence in the aging tissue is merely induced or it is this presence that induces aging.

Hsp60 is involved in protein folding and hsp70 has a role in regulating the heat shock response as well as membrane translocation. While hsp60 is found in the mitochondria, hsp70 is found in the eukaryotic cytosol, ER and mitochondria. Both families of proteins actually function for protein translocation and transport as well as folding and assembly (“Molecular Chaperones”). In aging and diseased tissues, high amounts of hsp60 are found in people with atherosclerosis, acute coronary syndromes and angina, while hsp70 is found in those with peripheral as well as renal vascular diseases (Frostegard & Pockley 201-202).

A number of experts and experiments in the field of molecular biology are pointing out that chaperones are the ones that bring about the aging process at the molecular level. Soti and Csermely, in their study entitled “Chaperones and aging: role in neurodegeneration and in other civilizational diseases, underlined the possibility that HSPs “might contribute to the onset of…atherosclerosis, cancer, diabetes and several neurodegenerative diseases” (384). In an actual experimental study in Korea, it was confirmed that the HSPs “might be involved in tumorigenesis” as it did in patients with hepatocellular carcinomas (Lim et al. 2077). This is so because, as proven by rodent experiments, “HSPs are known to be essential for the survival of cancer cells in different cancers” (Lim et al. 2077). Moreover, one particular HSP, hsp90, is believed to “[maintain] the functional quality of proteins involved in the progression of cancer” (Lim et al. 2077). Another HSP, hsp27, is also involved in promoting “accelerated growth and senescence” in bovine endothelial cells (Morrow & Tanguay 209).

These aforementioned statements somehow suggest that HSPs, presumably including all types and hsp60 and hsp70, may actually induce diseases, which may translate as a role in promoting cellular destruction and aging, instead of inhibiting these events. This conclusion, however, does not take into consideration the possibility that hsp70 and hsp60 may have other functions aside from possibly inducing aging and senescence. On the other hand, other findings suggest that HSPs are produced by aged cells only as a form of an “adaptive response” or as a way to “prevent protein aggregation and to assist in refolding, or degradation,” which are actually cellular reactions to the aging process (Soti & Csermely, “Molecular Chaperones” 227).

Studies of stressed cardiac muscle leading to increased production of hsp70 somehow also demonstrate that such an increase is linked to “myocardial protection” (Broome et al. 85). Moreover, it is possible that “HSP could function to slow the rate of aging” particularly for hsp70 because of a reduction of its production in aged rats (Morrow & Tanguay 209). This means that since there is less hsp70 in aging tissue, then aging is taking place at a regular or fast rate, while since there is more hsp70 in young tissue, then aging is taking place at a slower rate.

Still, in another study, “exercise has been shown to induce the release of hsp70 into the peripheral circulation of normal individuals” (Frostegard & Pockley 201). Since exercise is associated with cellular repair and youth, then its subsequent production of hsp70 must also be associated with the same events. Aging is caused by alterations in pH, hypoxia and oxidative stress, and there is a corresponding increase in HSPs in cells, particularly hsp70 (Broome et al. 85).

&nbsp.Although experimental data have established the possibility of such a role, it must nevertheless still be defined. Moreover, current data mostly account for the general function of HSPs as well as the specific functions of hsp70, but very little on hsp60. Hence, until everything has been cleared by further experiment and research, nothing much can be concluded regarding the roles of hsp60 and hsp70 in aging.

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writing homework on Emily Brontes Narration in Wuthering Heights. Write a 1500 word paper answering;

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Need help with my writing homework on Emily Brontes Narration in Wuthering Heights. Write a 1500 word paper answering;

The essay “Emily Bronte’s Narration in Wuthering Heights” presents the analysis of “Wuthering Heights” as the only novel written by Emily Bronte and can be considered the greatest reflection of her craftsmanship and creativity. A variety of narrators and different narrative techniques resulted in a multi-layered narration. Bronte’s attempts to make this character special by means of his using a dialect has not always been approved by the critics. Vice versa, they used to claim that Bronte had serious technical problems while presenting to the readers Joseph’s speech: “This is t’way on’t-up at sun-dahn. dice, brandy, cloised shutters, und can’le lught till next day, at nooin-then, t’fooil gangs banning un raving tuh his cham’er, makking dacent fowks dig thur fingers i’ thur lugs fur varry shaume. un’ th’ knave, wah, he carn cahnt his brass, un’ ate, un’ sleep, un’ off tuh his neighbour’s tuh gossip wi’ t’ wife”.

The reader who is aware of Yorkshire dialect can interpret these words correctly. The rest of readers read these lines like a chain of mystifying information. Another character who was supposed to speak some kind of dialect but he really was not Heathcliff. Though, his speech was described as “unintelligible” and it refers to his status of “the gipsy-the plough boy”. Therefore, Heatchcliff is a violent character and though Bronte does not exactly encode his speech to the readers, she does not intend to correlate Victorian virtue by means of Standard English.

Create a thesis and an outline on E-Commerce of Light in The Box. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required.

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I need help creating a thesis and an outline on E-Commerce of Light in The Box. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required.

As an online store, it is important for customers to always go through the store’s FAQs and other policy issues. This is important in ensuring that customers understand how the store operates in terms of making orders, cancellations, returns, or exchanges.&nbsp. The website has been designing in such a way that it is easier for customers to explore and place orders for the products that they prefer. However, prior to placing orders, it is important for customers to thoroughly review the store’s return policies. The products that this online shopping center deals in include women’s clothing, dresses, electronics, and shoes among other product categories that may interest customers. Online shopping mainly denotes purchasing products or other services via the internet. This type of shopping is now popular across the globe as a result of advancement in the use of ICT, it is considered to be convenient and also attract lower prices. This is more so during the holiday season where shoppers are able to avoid the hectic process of visiting several stores physically or standing in long queues in order to purchase a certain item (.Jifeng, Sulin & Han 2012, p.1131). This paper provides a critical discussion of the business of Lightinthebox.com, an online shopping store.

The current business environment of Lightinthebox.com

This online shopping store mainly sells goods produced in China to other parts of the world. The products that this online store retail is considered to be affordable and targets every hobby or lifestyle by customers across the globe. At the moment, the products that the store retails include home improvement, fashion, beauty products, and electronics among other products that are in high demand globally. Lightinthebox.com provides customers with an easy way of shopping. thus, allowing customers to cut unnecessary costs for purchasing a product in conventional stores. The store has different payment options that provide convenience to customers across the world. This includes the use of credit cards, wire transfers, PayPal, or debit cards to make payments (Panda & Narayan 2013, p.52).

At this point, you should be gathering information and research about the definition of your theme. In about 5 sentences, briefly summarize what you have learned about your theme so far. Good research should teach the researcher some new things. What is the most surprising thing you have learned so far in your research about your theme? 

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Discussion #2

Respond to each question below.

1.  At this point, you should be gathering information and research about the definition of your theme. In about 5 sentences, briefly summarize what you have learned about your theme so far. Good research should teach the researcher some new things. What is the most surprising thing you have learned so far in your research about your theme?  (150 WORDS)

2.  In his TED Talk, David Peterson suggests that “Basically, language is the most important thing in the entire world. All of our civilization rests upon it.” Do you agree with these statements? Why or why not? Respond in about 7 sentences. (100 WORDS)

3. Reflect on the theme you’ve chosen to study this semester. How might “civilization rest upon” that theme, in some way? Why is your theme important as a component of language? Make at least one specific connection to the Peterson TED Talk, and respond in about 5 sentences.

(100 WORDS)

prepare and submit a term paper on Managing Change as a Youth Work Manager. Your paper should be a minimum of 2750 words in length.

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You will prepare and submit a term paper on Managing Change as a Youth Work Manager. Your paper should be a minimum of 2750 words in length.

These elements will be mentioned, in relation to youth work management, to determine the factors that make such a manager successful in an environment of dynamic financial and political changes. Youth service agencies, which used to receive generous allocations as part of the Labour government’s policies towards youth empowerment, have been forced to contend with decreasing funding since the economic crisis of 2008/2009 (Stoner et al. 2012: p54). Funding decreased significantly between 2012 and 2013 for the majority of youth services and this trend is expected to continue as the recession recovery continues to be slower than expected.

The effects of this trend have substantially changed the landscape for youth services compared to 5-10 years ago. While youth work service would offer more diverse services aimed at improving youth autonomy, achievement, and involvement, current services are aimed at tackling existing youth problems, rather than youth empowerment. This can be seen in the concerns over the reduction of youth programs that has diverted attention away from youths with complex needs, compared to current services that are targeted at specific problems (Tyler, Hoggarth, & Merton, 2009: p43).

The withdrawal of funding to the Future Jobs Fund is another example of the changes to youth work service provision. What this has meant is that services have increasingly turned their attention away from creating jobs for the unemployed young people. Similar trends are also evident in pilot programs aimed at providing young people with incentives and support to involve themselves in activities that increased employment opportunities, as well as training opportunities (Dixon, 2013: p9).&nbsp.

research paper on optimising squatting technique. Needs to be 5 pages.

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Need an research paper on optimising squatting technique. Needs to be 5 pages. Please no plagiarism.

Squats strengthen critical muscles in the body for instance. soleus, Sartorius, and glutes. They also reinforce the back chain of muscles that include. the hamstring, glute, and calves. Through doing squats as an exercise, an individual will be able to burn calories thus getting rid of extra fats from the body. Squats enhance the general body endurance as they will facilitate accomplishing other tasks and sporting activities (Strossen, 1989).Squatting involves five distinct steps that ought to be to achieve the best results.

If squatting is not done in the right manner, it will lead to other problems since the person involved may develop irregular body growth due to lack of balance during the entire course. To begin with, the individual is supposed to grab the bar with a medium grip. The feet should be positioned directly below the bar assuming a perpendicular angle. The bar should be put on the rear shoulder and the traps during the shoulder being up with the upper back muscles remaining tight (Puddu, Giombini, & Selvanetti, 2001).

The next step involves unracking the bar from its position by squatting up. It is achieved by the person taking a single backward step with one leg. After the bar has checked into position, you should stand steadily while the hips should lock to ensure maximum stability.Next, the individual should take a deep breath and hold it as he/she prepares to make the squat. The knees are pulled to the side while the hips move backward and downwards. The motion should continue to the point one breaks parallel.

Breaking parallel is a position whereby the hips are below the knees (Magill et al., 2014).After breaking parallel, you should hold your breath while at the bottom. The entire movement is reversed by driving the hips upwards. The knees should be maintained out with the chest up, and the upper back muscles remaining tightly held to support the body from collapsing.

Compose a 250 words assignment on women in advertising.

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Compose a 250 words assignment on women in advertising. Needs to be plagiarism free!

Analysis Assignment #4 on Women in Advertising To begin with one should say that advertising today is one of theintegral phenomena of modern life. On its second position designated the social roles of men and women which they have to carry out. Advertising images are simplified and stereotyped, but in such form they influence people, forcing them not only to buy goods, but also reflect in their behavior. In addition to this, very often advertising describes public relations, including gender relations.

Simplified nature of sexual roles, forms their similar treatment in life of each certain individual, this means that, besides the main function (to force the buyer to choose these goods), advertising carries one more function which is social (it creates public relations). Furthermore, advertising transfers the social status or individual feeling concerning certain product. There you will never hear or see the simple words “Buy this!”, this may be substituted by the other phrase. In general, they speak about things that you cannot buy for money.

One cannot deny the fact that the image of woman from antiquity in all cultures is an embodiment of sexuality and fertility. That is why the majority of the ads are focused on men’s audience, contains an image of the woman: the temptress and fatal beauty with roundish, convex forms. As a rule, women in such advertising show half naked body or its parts in seductive poses that denotes an open hint on sex. Finally, the romantic image in it has rather big impact on audience as it casts thoughts of the finest and strong feeling on the earth as love.

For this reason we admire such beauty, and women imagine themselves on their place and dream to be in embraces of the defender.

Works Cited

“Killing Us Softly 3: Advertisings Image of Women.” YouTube. 2009. Web. 26 Sep.

submit a 250 words paper on the topic Discussion Board 1 AC.

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Hi, need to submit a 250 words paper on the topic Discussion Board 1 AC.

Kiowa People by Scott Momaday tells the story of the ancient tribe called Kiowa to which his grandmother belonged. Firstly he concentrates on the landscapes where the people lived and finds some correlation between the places and the mentality of the tribe. He seems to feel great affection to each place he describes, like every detail acquires some specific meaning for him:“The long yellow grass on the mountain shone in the bright light, and a scissortail hied above the land”.He stops on colors, textures, sounds of the environment around him.

Momaday seems to feel some nostalgia accompanied with some eternal sadness, but not the sadness which appears when something is gone for good. His blue mood is calm and simple, he wants to learn some answers on the eternal question of life and death. And he seems to understand something in the land of Kiowa. The author emphasizes the fact that his grandmother spent a great deal of time praying, trying to understand her meaning in life. Momaday does not mention his addressing to God, however, his desire to learn more about the land and the people which lived there is also a quest or a prayer.

Narrative is aimed to describe and to connect some past events, make them real for listeners or readers. Our life can also be regarded as narrative because it appears as the stories that we tell each other. Learning about his grandmother and her people the author creates narrative which helps him bring to life these people from nowhere. Narrative, however, is most often symbolic meaning that it has sense for the author only. But in this case Momaday express his gratification and respect to his grandmother.

Writing paper on isaac newton on essence of god

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I need some assistance with these assignment. isaac newton on essence of god Thank you in advance for the help!

History Isaac Newton is known for inventing the law of gravity which by far is applied in almost every day activities. By universal law, Newton meant the dependence in attraction between earth and all other objects whether on earth or in air. This universal law states that the gravitational attraction between the earth and other objects is inversely proportional to the distance that separates the earth’s centre from that object’s centre. This law was derived through four rules. First was the admission that there are no causes of natural things that are true or sufficient in explaining their appearance (Newton, 54).

The second rule is that due to lack of truth and sufficiency in the explanation of appearance of things, same natural effects must be assigned to the same cause. Here, he gave the example of how man and beast respire as well the difference of light from culinary fire and that from the sun. Third example was that of qualities belonging to bodies that humans can have access to during experiments and therefore such qualities can be esteemed as the universal qualities for all bodies. From this rule he deduced that all bodies are impermeable and are movable, endowed with some powers that help them in resisting motion (Newton, 54).

In addition, all bodies gravitate towards the earth with a proportion of their quantity of matter. Examples of such are the way the sea gravitate towards the moon or the motion of planets towards each other.

According to Newton, God is the overall creator of the universe. He states that “this most beautiful system of the sun, planets and comets could only proceed from the counsel and dominion of an intelligent and powerful Being.” This shows that Newton acknowledges that the universe and all that is in was created not by human being but one Super Being, God.

He continues to explain that the Creator of the universe is one intelligent Being and has dominion over the entire universe (Newton, 55). To show the wise counsel of the one who made the universe be, he states that despite the fixed stars being placed at the centre of the systems and them producing same light as the sun, they do not fall on each other like they should. This is because the creator has placed these systems at colossal distances from each other (Newton, 55). Notably, Newton recognizes that the creator of the universe governs it not as the “soul of world” but as the “Lord overall”.

Also, Newton states that “it is the dominion of a spiritual being which constitutes a God and from His true dominion it follows that the true God is a living, intelligent and powerful being.” These are the attribute that he gives to God as the ruler of the universe. He writes all things are contained and moved by God and that nothing affects the other (Newton, 55). The bodies in universe do not face any resistance from God’s omnipresent nature. Therefore, Newton acknowledges that all things in universe are created and sustained by God.

The connection that exists between the document and the present is that despite the generation difference, God still is and will always be the creator and container of the universe. Despite all the scientific discoveries, Newton still remains the one single person who opened the path for others to know about the universe and the forces that contain it but he still acknowledged that there is that one Being who controls it. In conclusion, despite science taking over in most of our daily activities, we should revere the one who created the universe like Isaac Newton did.

Works Cited

Newton, Isaac. The principia: mathematical principles of natural philosophy. California: University of California Press, 1999.

research paper on language development in animals and humans. Needs to be 11 pages.

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Need an research paper on language development in animals and humans. Needs to be 11 pages. Please no plagiarism.

It allows for understanding the way the language is acquired and employing this to teach and learn foreign languages and correct the possible errors of the mother tongue. Language acquisition presupposes the development of four key language skills: listening, reading, speaking, and writing. According to today’s psychological theories, the native language (together with the second one, in the case of bilingualism) is developed completely in the years of childhood, while foreign languages are mastered during the entire lifetime.

The development of language in humans is important to study because of practical reasons, such as languages studying and teaching and increasing of efficiency of these processes, and from the theoretical perspective to understand why this phenomenon is observed only in human beings and how it distinguishes a human being from other species of the animal world.The method of research which will be used in this article is the analysis of the information from the academic journal articles related to the topic of the present research paper.

The use of the above-mentioned research method makes it possible to give the results of the literature studying in terms of language development from a psychological point of view. To better understand the results of the studies it is necessary to give short definitions of general concepts, such as language and language development.It is possible to give such a definition of a language: “an organized system of arbitrary signals and rule-governed structures that are used as a means for communication”.

(Brandone, Salkind, Hirsh-Pasek 2006). Everyday life of modern society is impossible without language because it is necessary to exchange information to support the functioning of each element, a human being: employing language people receive important information, such as dates of certain events, different timetables, working schedules, and many other pieces of information which regulate and influence their activity. Language can also be used for transmitting information without direct communication of its speakers, for example, employing advertisements, commercials, or other means of external information placement.